Post-doc Fellow: In-Vivo Neuropharmacology
Requisition ID: 1905714313W
Janssen Research & Development, a division of Janssen Pharmaceutica NV, has opened up an excellent post-doctoral research opportunity at its site in Beerse, Belgium. We are seeking a highly motivated, independent and passionate post doctoral researcher to join our multinational Global Safety Pharmacology research group.
Global Safety Pharmacology is an expert center that supports our therapeutic areas across the globe with advice, safety testing and research from discovery, through clinical development and up to marketed product. The lab focuses on the safety pharmacology assessment of new chemical entities on vital organ systems, such as the heart, lungs and brain.
In drug development the top priority is to select safe and sustainable new drug candidates for further development. Over the last 6-8 years, drug-induced seizure liability has unfortunately become a major challenge for the pharmaceutical industry as they pursue relatively unexplored new potential drug targets for diseases of unmet need. In addition, species differences in drug-induced convulsion, creates a major challenge to correctly identify seizurogenic/convulsion risk in the non-clinical environment when looking toward clinical translation. This post-doctoral position will support the development of research capabilities/assays for the team, investigate potential species differences and to help deconvolute the potential mechanisms of action of in-vivo seizure/convulsion liabilities of new drug candidates. The candidate will have the opportunity to develop unique innovative in-vivo models (small and large animals e.g. rat and dog respectively) with combined cardiovascular (ECG and hemodynamics) and CNS measurements (EEG & behaviour analysis). Special consideration will be given to candidates with experience within the field of epilepsy research.
Key job responsibilities:
- The role will primarily be
responsible to Identify seizurogenic effects/liabilities of a new drug
candidate during the discovery and development phases by creating novel innovative
in-vivo methods/models where CNS (EEG and behaviour analysis) and CVS (ECG,
hemodynamics) would be measured together.
- Research into better
understanding seizures found during safety screening.
- Development and the mechanistic
role of ion channel/GPCRs/transporters in the brain related to
- The successful candidate will
also have the possibility to work in close collaboration with in-vitro neuronal
expert scientists within Janssen to look at potential species differences
- Understand the off or on target
mechanisms of action and in-vitro to in-vivo translational relevance of models.
Education & experience
• A post-doc / Ph.D. in neuroscience/ neuropharmacology / neurophysiology or related fields with 0 - 3 years of experience• Experience in in-vivo epilepsy/seizure research, EEG recording in small and/or large animals is preferred
• Behavioral analysis experience would be advantageous
• In vivo neuroelectrophysiology experience would be advantageous• Although training will be given, expertise with surgical procedures and preferably experience in using radio telemetry implantation devices for EEG recording would be advantageous
- Johnson & Johnson companies
are equal opportunity employers.
- Some knowledge of surgical
techniques, instruments, analysis: Physiological continuous measurement
techniques (e.g. EEG, neuro-electrophysiological measurements), telemetric
techniques, data analysis, interpretation and reporting.
- Excellent written and oral
English communication skills required.
- Highly motivated to learn new
techniques and develop new hypotheses
- Some training for the
successful candidate will be given by our scientists/surgeons but there is an
expectation of at least basic surgical and analytical skills have already been
obtained with prior experience.
What’s in it for you…?
“Caring for the world, one person at a time…”
As an employee we consider you as our most valuable asset. We take your career seriously.
As part of a global team working in an innovative environment, your development is key and our day-to-day responsibility.
Through a highly interactive and connected post-doc community within Janssen, e-university, on the job training, various projects and programs,
we ensure your personal growth.
Our benefits make sure we care for you and your family now and in the future.
Janssen Pharmaceutica N.V. (7555)